Imagine those properties of things :
Knots K of different geometries.
Ropes R of different materials.
Forces F of different sizes.
Each combination of properties corresponds to one physical object O :
For example, if knot Kx is tied, rope Ry is tangled, and force Fz is applied on each end, we have the object / materialized knot / knotted material Oxyz = Kx/Ry/Fz - and so on, for all possible combinations of knot geometries, rope materials and force sizes.
Conjecture about the easiness of untiability :
If one object O1, tied with knot K1, tangled on rope Ri and tightened by force Fi, is easier to untie than another object O2, tied with knot K2, tangled on the same rope and tightened by the same force, then all objects tied with knot K1, tangled on any rope, and tightened by any force, will be easier to untie than their corresponding objects tied with knot K2.